Infertility

A multi-center international prospective study conducted by researchers at the University of Milan, several additional facilities in Italy and St.

Elizabeth Medical Center in Brighton, MA evaluated capsule endoscopy's ability to detect villous atrophy, the flattening of the villi, in patients with suspected celiac disease compared to an upper GI endoscopy.

All 43 patients in the study underwent both upper endoscopy and capsule endoscopy.

Gastroenterologists were blinded to each patient's upper GI and pathology results when evaluating the capsule endoscopy findings.

Authors concluded that 32 patients had mucosal changes compatible with celiac disease.

The results showed that the capsule led physicians to make a correct positive diagnosis in 87.5% of the cases where upper GI had confirmed villous atrophy.

Specificity (the ability to avoid a false positive), positive and negative predictive values were 90.9%, 96.5%, 71.4% respectively.

Additionally, capsule endoscopy correctly diagnosed celiac disease in one patient where upper endoscopy and biopsy had ruled out disease.

What was initially thought to be a "false positive" from CE turned out to be a "false negative" on the part of upper endoscopy and biopsy.

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